Review article: the non-inherited gastrointestinal polyposis syndromes

• Published in: Alimentary pharmacology & therapeutics Vol. 16; no. 3; pp. 333 - 342
• Main Authors: WARD, E. M, WOLFSEN, H. C
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01-03-2002
• Subjects: Adrenal Cortex Hormones - therapeutic use; Anti-Bacterial Agents - therapeutic use; Biological and medical sciences; Drug Combinations; Gastroenterology. Liver. Pancreas. Abdomen; Histamine Antagonists - therapeutic use; Humans; Hyperplasia - pathology; Hyperplasia - therapy; Intestinal Polyps - pathology; Intestinal Polyps - therapy; Medical sciences; Nutritional Support; Other diseases. Semiology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Syndrome; Human; Chemotherapy; Treatment; Cronkhite Canada syndrome; Digestive diseases; Complication; Intestinal disease; Inflammation; Review; Diagnosis; Gastric disease; Polyp
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1046/j.1365-2036.2002.01172.x

The non-inherited gastrointestinal polyposis syndromes represent a group of rare disorders characterized by the presence of multiple, non-adenomatous polyps on the gastrointestinal mucosa occurring in unrelated patients. We present here a review of the clinical and histo- pathological aspects of the syndromes to include the Cronkhite-Canada syndrome, hyperplastic polyposis and lipomatous polyposis. While infrequently encountered, these diseases can have devastating clinical effects that may be aggravated by delays in diagnosis and treatment. Prompt accurate diagnosis and treatment of these uncommon disorders depend on a sound working knowledge of the distinct clinical and pathological features described herein.