Synthesis of new 2-substituted-[1,3,4]-oxadiazino-[6,5-b]-indoles with H1-antihistaminic, antimuscarinic and antimicrobial activity [corrected]

New 2-substituted-[1,3,4]-oxadiazino-[5,6-b]-indoles have been prepared and tested for their antibacterial, antifungal, H1-antihistaminic and antimuscarinic activities. Among them, compounds 5b, 5d, 5k exhibited higher H1-antihistaminic activity than pheniramine maleate. Compounds 5c, 5d showed high...

Full description

Saved in:

Bibliographic Details
Published in:	Pharmazie Vol. 57; no. 12; p. 796
Main Authors:	Ajitha, M, Rajnarayana, K, Sarangapani, M
Format:	Journal Article
Language:	English
Published:	Germany 01-12-2002
Subjects:	Animals Anti-Bacterial Agents Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Bacteria - drug effects Chemical Phenomena Chemistry, Physical Fungi - drug effects Guinea Pigs Histamine H1 Antagonists - chemical synthesis Histamine H1 Antagonists - pharmacology Ileum - drug effects In Vitro Techniques Indoles - chemical synthesis Indoles - pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Muscarinic Antagonists - chemical synthesis Muscarinic Antagonists - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	New 2-substituted-[1,3,4]-oxadiazino-[5,6-b]-indoles have been prepared and tested for their antibacterial, antifungal, H1-antihistaminic and antimuscarinic activities. Among them, compounds 5b, 5d, 5k exhibited higher H1-antihistaminic activity than pheniramine maleate. Compounds 5c, 5d showed higher antibacterial activity than ampicillin against Staphylococcus aureus and E. coli, respectively.
ISSN:	0031-7144