Necrotizing fasciitis of previous surgical wound complicating intensive postremission chemotherapy

• Published in: Journal of the Medical Association of Thailand Vol. 74; no. 2; p. 108
• Main Authors: Intragumtornchai, T, Laongsiri, P, Mahasandana, S, Wanakrairoj, P, Dhanapongsathorn, V, Rajatapiti, B
• Format: Journal Article
• Language: English
• Published: Thailand 01-02-1991
• Subjects: Adolescent; Agranulocytosis - chemically induced; Agranulocytosis - complications; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Appendicitis - complications; Appendicitis - surgery; Cytarabine - administration & dosage; Doxorubicin - administration & dosage; Escherichia coli Infections - etiology; Escherichia coli Infections - pathology; Escherichia coli Infections - therapy; Fasciitis - etiology; Fasciitis - pathology; Fasciitis - therapy; Humans; Leukemia, Myeloid, Acute - complications; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - drug therapy; Male; Surgical Wound Infection - etiology; Surgical Wound Infection - pathology; Surgical Wound Infection - therapy
• ISSN: 0125-2208

Necrotizing fasciitis of previous surgical wound developed in a leukemic patient after receiving intense postremission chemotherapy. A unique feature was profound granulocytopenia and the recovery of Escherichia coli in the blood and necrotic tissue. We believe the hematogenous seeding of the surgical wound during the episode of E. coli septicemia was the cause of our patient's necrotizing fasciitis.