Sulphasalazine-induced reversible male infertility

A male patient suffering from ulcerative colitis, presented with primary infertility due to sulphasalazine therapy. Sulphasalazine was discontinued and the patient was treated with a 5-aminosalicylic acid preparation (Salofalk) in the form of an enema. After 3 months, the semen quality was dramatica...

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Bibliographic Details
Published in:	Acta urologica Belgica Vol. 57; no. 1; p. 29
Main Authors:	Delaere, K P, Strijbos, W E, Meuleman, E J
Format:	Journal Article
Language:	English
Published:	Belgium 1989
Subjects:	Adult Aminosalicylic Acids - therapeutic use Colitis, Ulcerative - drug therapy Follicle Stimulating Hormone - blood Humans Infertility, Male - chemically induced Luteinizing Hormone - blood Male Mesalamine Sperm Count - drug effects Sperm Motility - drug effects Sulfasalazine - adverse effects Testosterone - blood
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Summary:	A male patient suffering from ulcerative colitis, presented with primary infertility due to sulphasalazine therapy. Sulphasalazine was discontinued and the patient was treated with a 5-aminosalicylic acid preparation (Salofalk) in the form of an enema. After 3 months, the semen quality was dramatically improved and a successful pregnancy ensued. The sulphapyridine moiety of sulphasalazine seems to be responsible for male infertility and depressed semen quality. The metabolite 5-aminosalicylic acid is proposed as a suitable alternative to sulphasalazine in cases of male infertility.
ISSN:	0001-7183