Phyto-fabricated Cr2O3 nanoparticle for multifunctional biomedical applications

• Published in: Nanomedicine (London, England) Vol. 15; no. 17; pp. 1653 - 1669
• Main Authors: Hamza Elsayed Ahmed Mohamed, Afridi, Shakeeb, Ali Talha Khalil, Tanzeel Zohra, Ali, Muhammad, Muhammad Masroor Alam, Ikram, Aamer, Zabta Khan Shinwari, Malik Maaza
• Format: Journal Article
• Language: English
• Published: London Future Medicine Ltd 01-07-2020
• Subjects: Antimicrobial agents; Antioxidants; Biosynthesis; Cancer; Free radicals; Kinases; Metal oxides; Microscopy; Nanomaterials; Nanoparticles; Nanotechnology
• ISSN: 1743-5889; 1748-6963
• DOI: 10.2217/nnm-2020-0129

Aim: The biosynthesis of chromium oxide nanoparticles (Cr2O3 NPs), using Hyphaene thebaica as a bioreductant, for assessment of their potential nanomedicinal applications. Materials & methods: Biosynthesized Cr2O3 NPs were characterized by x-ray diffraction, Fourier-transform infrared spectroscopy, energy dispersive x-ray spectroscopy, scanning and transmission electron microscopy, selected area electron diffraction, UV–Vis spectroscopy and ζ-potential measurement. In vitro assays were used to assess the biological properties of Cr2O3 NPs. Results: Nanoparticles with size approximately 25–38 nm were obtained with a characteristic Cr–O vibration at 417 cm-1. A broad spectrum antimicrobial potential and antioxidant nature is reported. Slight inhibition of polio virus and biocompatibility at low doses was observed. Conclusion: We conclude a multifunctional nature of biogenic Cr2O3 NPs.