Further studies of immunoglobulin synthesis by guinea pig leukaemic lymphocytes

The L2C leukaemia is a B-lymphocytic neoplasm of strain 2 guinea-pigs, maintained by passaging in vivo. It synthesizes mu and lambda immunoglobulin chains. These combines to form monomeric (7S) IgM molecules which are inserted into the plasma membranes. From here they are shed as monomeric IgM and a...

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Bibliographic Details
Published in:	Immunology Vol. 34; no. 5; pp. 889 - 899
Main Authors:	Hough, D W, Chapple, J C, Stevenson, F K, Stevenson, G T
Format:	Journal Article
Language:	English
Published:	England 01-05-1978
Subjects:	Animals Cells, Cultured Guinea Pigs Immunoglobulin Fragments - biosynthesis Immunoglobulin lambda-Chains - urine Immunoglobulins - biosynthesis Leukemia, Experimental - immunology Lymphocytes - immunology Lymphocytes - metabolism Papain Receptors, Antigen, B-Cell - biosynthesis
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Summary:	The L2C leukaemia is a B-lymphocytic neoplasm of strain 2 guinea-pigs, maintained by passaging in vivo. It synthesizes mu and lambda immunoglobulin chains. These combines to form monomeric (7S) IgM molecules which are inserted into the plasma membranes. From here they are shed as monomeric IgM and as a species of higher molecular weight which has not been further defined. The synthesis of lambda chain is in excess of that required for the IgM molecule, the surplus being exported directly from the cell without any intervening phase in the plasma membrane. Quantitative estimates of synthetic rates and pool sizes for these immunoglobulin species are presented.
ISSN:	0019-2805 1365-2567