Animal Models of Depression: Behavior as the Basis for Methodology, Assessment Criteria and Classifications

• Published in: Zurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 65; no. 6; p. 643
• Main Authors: Grigoryan, G A, Gulyaeva, N V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-11-2015
• Subjects: Animals; Behavior, Animal - physiology; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Depression - genetics; Depression - metabolism; Depression - physiopathology; Disease Models, Animal; Emotions - physiology; Encephalitis - metabolism; Encephalitis - physiopathology; Humans; Memory - physiology; Mice; Neurons - metabolism; Neurons - pathology; Neurons - physiology; Rats; Serotonin - metabolism; Serotonin - physiology
• ISSN: 0044-4677
• DOI: 10.7868/S0044467715060052

Analysis of the current state modeling of depression in animals is presented. Criteria and classification systems of the existing models are considered as well as approaches to the assessment of model validity. Though numerous approaches to modeling of depressive states based on disturbances of both motivational and emotional brain mechanisms have been elaborated, no satisfactory model of stable depression state has been developed yet. However, the diversity of existing models is quite positive since it allows performing targeted studies of selected neurobiological mechanisms and laws of depressive state development, as well as to investigate mechanisms of action and predict pharmacological profiles of potential antidepressants.