Expression of metalloproteinase-9 in patients with mild and severe forms of gastroesophageal reflux disease

• Published in: Cirugia y cirujanos Vol. 87; no. 4; p. 436
• Main Authors: Montiel-Jarquín, Álvaro J, Lara-Cisneros, Luis G Vázquez de, López-Colombo, Aurelio, Solís-Mendoza, Hugo A, Palmer-Márquez, María L, Romero-Figueroa, María S
• Format: Journal Article
• Language: English; Spanish
• Published: Mexico 2019
• Subjects: Adult; Aged; Aged, 80 and over; Barrett Esophagus - enzymology; Barrett Esophagus - etiology; Body Mass Index; Chi-Square Distribution; Cross-Sectional Studies; Esophageal Neoplasms - enzymology; Esophageal Neoplasms - etiology; Esophagitis - enzymology; Esophagitis - etiology; Esophagus - enzymology; Female; Gastroesophageal Reflux - complications; Gastroesophageal Reflux - enzymology; Humans; Male; Matrix Metalloproteinase 9 - metabolism; Middle Aged; Observer Variation; Sensitivity and Specificity; Smoking - metabolism; Young Adult; Adenocarcinoma esofágico; Enfermedad por reflujo gastroesofágico; Metaloproteinasa-9; Barret’s esophagus; Gastroesophageal reflux disease; Metalloproteinase-9; Esófago de Barrett; Esophageal adenocarcinoma
• ISSN: 2444-054X
• DOI: 10.24875/CIRU.18000691

Gastroesophageal reflux disease develops when the stomach contents causes troublesome symptoms and complications. Mild forms are non-erosive and erosive esophagitis, and severe forms are Barrett's esophagus and Esophageal adenocarcinoma. Matrix metalloproteinases are endopeptidases that can degrade components of the extracellular matrix, they play an important role in tumor invasion as well as in metastasis.
To correlate the expression of metalloproteinase 9 (MMP-9) in esophageal biopsies from patients with mild and severe forms of Gastroesophageal reflux disease.
Cross-sectional study. The expression of MMP-9 was determined in biopsies of esophageal tissue of patients with mild and severe GRD. The included variables were age, sex, diagnosis, smoking and alcoholic habits, body mass index (BMI) and expression of MMP-9. Descriptive statistics was performed, Kappa for concordance in diagnosis as well as X2.
There were 50 patients, 32 (64%) men and 18 (36%) women, mean age 52.13 ± 14.75 years of age. 12 (24%) with smoking and 7 (14%) with alcoholism. Average BMI was 26.71 ± 4.07 kg/m
(15 to 33); 40 (80%) with obesity. The inter observer concordance for histopathological diagnosis was 1.0 and 0.84 for esophagitis degrees. 27 (54%) patients had esophagitis, 16 (32%) Barrett's esophagus and 7 (14%) esophageal cancer. There was expression of MMP-9 in four patients with esophagitis, five with Barrett's esophagus and five with esophageal cancer. Statistical significance was found between the expression of MMP-9 and smoking (p = 0.011) and histopathological diagnosis (p = 0.052).
The expression of MMP-9 is most common in severe forms compared to the mild forms of GRD.