Fat-soluble vitamins supplementation in patients with cystic fibrosis: is enough Aquadek's®?

• Published in: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 31; no. 4; pp. 1625 - 1632
• Main Authors: González Jiménez, David, Bousoño García, Carlos, Díaz Martin, Juan Jose, Jiménez Treviño, Santiago
• Format: Journal Article
• Language: Spanish
• Published: Spain 01-04-2015
• Subjects: Adolescent; Adult; Avitaminosis - drug therapy; Avitaminosis - etiology; Child; Child, Preschool; Cystic Fibrosis - blood; Cystic Fibrosis - drug therapy; Dietary Supplements; Exocrine Pancreatic Insufficiency - complications; Exocrine Pancreatic Insufficiency - drug therapy; Female; Humans; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Tablets; Vitamins - administration & dosage; Vitamins - blood; Vitamins - therapeutic use; Young Adult
• ISSN: 1699-5198
• DOI: 10.3305/nh.2015.31.4.8281

Evaluate the safety and efficacy of a novel polyvitaminic (Aquadek's®) in patients with Cystic Fibrosis (CF).
Prospective, longitudinal and non-randomized study. CF patients with pancreatic insufficiency and clinically stable were given Aquadek's® (two chewable tablets) daily for 12 months. Serum levels of retinol, beta-carotene, 25 OH vitamin D and α-tocopherol were evaluated twelve months before, at baseline and 12 months after.
paired t tests.
28 patients aged 6 to 39 years (median 18.5 years) were included. Aquadek's® supplementation led to an increase in vitamin A dose and a decrease in the number of tablets administered. At baseline, 89% had at least one vitamin deficiency (61% pro-Vitamin A and 54% vitamin D). After one year, serum beta-carotene levels were increases 160 (95% CI 98-222) mcg/l (p <0.001) and decreased the percentage of patients with pro-vitamin A deficiency 46% (95% CI 22-64) (p <0.001). The proportion of patients with vitamin D insuficiency increased 18%(95% CI 2-32) (p =0.025). In any case serum levels exceeded the upper limits used to assess the risk of toxicity.Conclusions: Two daily Aquadek's® chewable tablets are safe and effective for maintaining vitamin A and E status of CF patients older than 6 years, although it is insufficient to normalize serum 25OHvitaminD according to the current recommendations for this disease.