Current aspects of neurogenic dysfunctions of the lower urinary tract in multiple sclerosis

• Published in: Nervenarzt Vol. 92; no. 4; pp. 349 - 358
• Main Authors: Domurath, Burkhard, Flachenecker, Peter, Henze, Thomas, Feneberg, Wolfgang, Brandt, Anna, Kurze, Ines, Kirschner-Hermanns, Ruth, Kaufmann, Albert, Bremer, Jörn, Vonthien, Manuela, Ratering, Kerstin, Schäfer, Christoph, Vance, Will Nelson, Schmidt, Paul
• Format: Journal Article
• Language: German
• Published: Germany 01-04-2021
• Subjects: Humans; Multiple Sclerosis - complications; Multiple Sclerosis - diagnosis; Prospective Studies; Urodynamics; Urologic Diseases; Urodynamics; Multiple sclerosis; Assessments; Neurogenic lower urinary tract disorders (NLUTD); Bladder dysfunction
• ISSN: 1433-0407
• DOI: 10.1007/s00115-020-01046-0

In the clinical management of patients with multiple sclerosis (MS), the challenge is to make an early diagnosis and initiate adequate treatment of neurogenic disorders of the lower urinary tract (NLUTD). Various national guidelines provide practical recommendations which are sometimes discordant.
To develop a simple evidence-based algorithm for detecting NLUTD in patients with MS that could be taken as a principle for deriving therapeutic consequences.
A prospective multicenter study was initiated as a direct result of two multidisciplinary conferences. The aim was to identify statistically and clinically relevant parameters for the routine diagnosis of NLUTD in patients with MS. Urodynamic abnormalities served as the gold standard. At three subsequent consensus conferences, the results of the study were discussed, a diagnostic algorithm was developed and consensus was reached on a first-line treatment.
The proposed algorithm enables the detection of NLUTD in patients with MS with the help of four statistically significant predictors: 1) the residual urine volume, 2) the number of urinary tract infections (UTI) within the last 6 months, 3) the standardized micturition frequency and 4) the presence/absence of urinary incontinence. The newly developed algorithm has proved to be efficient with the following results: approximately 75% of the patients do not need a urodynamic examination for a first-line treatment decision. In 25% of cases, urodynamic examinations are essential for an adequate treatment decision. Routine assessments include the patient medical history, residual urine volume measurement, a micturition diary and a uroflowmetry (optional).