On the Functional Cross-Talk between Brain 5-HT1A and 5-HT2A Receptors

• Published in: Zurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 65; no. 2; p. 240
• Main Authors: Naumenko, V S, Bazovkina, D V, Kondaurova, E M
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-03-2015
• Subjects: 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology; Amphetamines - pharmacology; Animals; Behavior, Animal - drug effects; Body Temperature Regulation - physiology; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Dose-Response Relationship, Drug; Hypothermia, Induced; Ketanserin - pharmacology; Male; Mice; Mice, Inbred CBA; Piperazines - pharmacology; Pyridines - pharmacology; Receptor Cross-Talk - physiology; Receptor, Serotonin, 5-HT1A - metabolism; Receptor, Serotonin, 5-HT2A - metabolism; Serotonin Antagonists - pharmacology; Serotonin Receptor Agonists - pharmacology
• ISSN: 0044-4677
• DOI: 10.7868/S0044467715020094

We have found that activation of 5-HT1A receptor with 8-OH-DPAT (0.1, 0.5 and 1.0 mg/kg, i. p.) considerably and dose-dependently reduced the number of 5-HT2A receptor-mediated head-twitches, whereas 5-HT1A receptor blockade with WAY-100635 (0.5 and 1.0 mg/kg, i. p.), on the contrary, pro- duced significant enhancement of this 5-HT2A receptor functional response. At the same time 5-HTA receptor activation with DOI (0.5 and 1.0 mg/kg, i. p.) abolished the 5-HT1A receptor-mediated hypothermic reaction, whereas 5-HT2A receptor blockade with ketanserin (1.0 and 2.0 mg/kg, i. p.) increased this 5-HT1A receptor functional response. Moreover, we revealed that 5-HT2A receptor antagonist ketanserin (1.0 and 2.0 mg/kg, i. p.; or 20 and 40 nmol, i. c. v.) produced the considerable dose-dependent hypothermia. This ketanserin-induced (40 nmol, i. c. v.) hypothermic reaction was significantly attenuated by pretreatment with 5-HT1A receptor antagonist WAY-100635 (1.0 mg/kg, i. p.), indicating that 5-HT2A receptor-related hypothermic response is mediated, at least partially, via activation of 5-HT1A receptors. The obtained data indicate that 5-HTA and 5-HT2A receptors are able to modulate each other functional activity by means of bilateral functional cross-talk.