Serological diagnosis of congenital infections and algorithms to improve diagnostic efficacy

• Published in: Enfermedades infecciosas y microbiologia clinica Vol. 33 Suppl 2; p. 20
• Main Authors: García-Bermejo, Isabel, de Ory-Manchón, Fernando
• Format: Journal Article
• Language: Spanish
• Published: Spain 01-07-2015
• Subjects: Algorithms; Antibody Specificity; Communicable Diseases - congenital; Communicable Diseases - diagnosis; Female; Humans; Immunoenzyme Techniques; Immunoglobulin G - blood; Immunoglobulin M - blood; Infant, Newborn; Infectious Disease Transmission, Vertical; Luminescent Measurements; Pregnancy; Pregnancy Complications, Infectious - diagnosis; Serologic Tests - methods; Cytomegalovirus; Rubella; Erythrovirus B19; Serology; Infección congénita; Rubéola; Herpes simplex virus; Congenital infection; Trypanosoma cruzi; Toxoplasma gondii; Serología; Virus herpes simple; Human immunodeficiency virus; Virus de la inmunodeficiencia humana; Citomegalovirus; Treponema pallidum
• ISSN: 1578-1852
• DOI: 10.1016/S0213-005X(15)30011-2

Congenital infection is those transmitted by the mother to the fetus before delivery. It can occur transplacentally or by direct contact with the pathogen during birth or in the immediate postnatal period. Congenital infection can be due to viruses (rubella, cytomegalovirus, herpes simplex, varicella-zoster, hepatitis B and C virus, human inunodeficiencia, erythrovirus B19) as bacteria (Treponema pallidum) and parasites (Toxoplasma gondii and Trypanosoma cruzi). Serological diagnosis of congenital infection is based on both the knowledge of infectious serology in the mother, including the systematic serological screening and diagnostic aspects of the determination of IgM and confirmatory methods, IgG avidity tests, establishment of antibody profiles, and in the diagnosis the neonate. Serological diagnosis of congenital infection in the newborn is mainly based on the detection of specific IgM usually by immunoenzymatic assays or immunochemiluminescence techniques. In some instances it is important to perform the serological follow up of the newborn to confirm the congenital infection.