Thrombotic microangiopathy with anti-ADAMTS 13 antibodies revealing an acute Q fever

Q fever can commonly mimic systemic diseases, leading to several immunological manifestations. Thrombotic micro-angiopathies manifest as a spectrum of related disorders in the form of thrombocytopenic purpura and hemolytic uremic syndrome. We report a 77-year-old woman, who presented an acquired thr...

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Bibliographic Details
Published in:	La revue de medecine interne Vol. 33; no. 11; pp. 640 - 642
Main Authors:	Morel, N, Berthoux, E, Colombe, B, Bosseray, A, Massot, C
Format:	Journal Article
Language:	French
Published:	France 01-11-2012
Subjects:	ADAM Proteins - immunology ADAMTS13 Protein Aged Autoantibodies - blood Female Humans Q Fever - blood Q Fever - complications Q Fever - diagnosis Thrombotic Microangiopathies - blood Thrombotic Microangiopathies - etiology Thrombotic Microangiopathies - immunology
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Summary:	Q fever can commonly mimic systemic diseases, leading to several immunological manifestations. Thrombotic micro-angiopathies manifest as a spectrum of related disorders in the form of thrombocytopenic purpura and hemolytic uremic syndrome. We report a 77-year-old woman, who presented an acquired thrombotic microangiopathy with renal expression associated with the presence of anti-ADAMTS 13 antibodies, which occurred during an acute infection by Coxiella burnetii (acute Q fever). Auto-immune disorders are well-known in chronic or acute Q fever but to our knowledge, this is the first reported observation of thrombotic microangiopathy with anti-ADAMTS 13 antibodies.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1768-3122
DOI:	10.1016/j.revmed.2012.08.012