Evaluation of cardiovascular risk by the LAP index in non-obese patients with polycystic ovary syndrome

• Published in: Arquivos brasileiros de endocrinologia e metabologia Vol. 54; no. 7; pp. 630 - 635
• Main Authors: Costa, Eduardo Caldas, Sá, Joceline Cássia Ferezini de, Soares, Elvira Maria Mafaldo, Lemos, Telma Maria Araújo Moura, Maranhão, Técia Maria de Oliveira, Azevedo, George Dantas
• Format: Journal Article
• Language: Portuguese
• Published: Brazil 01-10-2010
• Subjects: Adolescent; Adult; Cardiovascular Diseases - etiology; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Obesity - diagnosis; Obesity - epidemiology; Polycystic Ovary Syndrome - physiopathology; Risk Assessment - methods; Risk Factors; Statistics, Nonparametric; Triglycerides - blood; Waist Circumference - physiology; Young Adult
• ISSN: 1677-9487
• DOI: 10.1590/S0004-27302010000700007

To analyze the cardiovascular risk of non-obese women with polycystic ovary syndrome (PCOS) by the LAP index (lipid accumulation product).
283 patients (18-34 years) assigned at the University Hospital of the Federal University of Rio Grande do Norte, Natal-RN, were divided into four groups: 1) lean PCOS (n = 35); 2) healthy lean (n = 162); 3) overweight PCOS (n = 28); 4) healthy overweight (n = 58).
Patients with PCOS showed higher values of the LAP index than healthy controls: lean (22.26 vs. 15.87 cm.mmol/L; p = 0.007); overweight (40.83 vs. 26.32 cm.mmol/L; p = 0.001). The percentage of women above the 75th percentile of the LAP index was also higher in the subgroups with PCOS: lean (17.1 vs. 6.8%; p = 0.04); overweight (37.5 vs. 13.8%; p = 0.01).
In our sample, patients with PCOS showed higher cardiovascular risk assessed by the LAP index in relation to healthy women, even in the absence of obesity.