The study of microcirculation in walls of chambers of the heart in patients with aortic stenosis in dependence on heart failure stage

• Published in: Kardiologiia Vol. 51; no. 6; p. 38
• Main Authors: Karas'kov, A M, Kamenskaia, O V, Klinkova, A S, Zheleznev, S I, Shmatov, D V, Astapov, D A, Demin, I I, Open, A B
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2011
• Subjects: Aortic Valve - pathology; Aortic Valve - physiopathology; Aortic Valve - surgery; Aortic Valve Stenosis - complications; Aortic Valve Stenosis - physiopathology; Aortic Valve Stenosis - surgery; Cardiac Valve Annuloplasty - adverse effects; Chronic Disease; Female; Heart Atria - pathology; Heart Atria - physiopathology; Heart Failure - etiology; Heart Failure - physiopathology; Heart Ventricles - pathology; Heart Ventricles - physiopathology; Hemodynamics; Humans; Hypertrophy; Laser-Doppler Flowmetry; Male; Microcirculation; Microvessels - physiopathology; Middle Aged; Regional Blood Flow; Severity of Illness Index; Treatment Outcome; Ventricular Remodeling
• ISSN: 0022-9040

We studied microcirculatory blood flow (MBF) by laser Doppler flowmetry (LDF) in 52 patients with stage III-IV aortic stenosis (AS) and class II-IV chronic heart failure (CHF). MBF was assessed in walls of right and left cardiac chambers before and after correction of the defect. Aim of this study was to assess functional state of MBF in walls of different chambers of the heart before and after defect correction in patients with AS at various stages of CHF. We distinguished 2 groups of patients: group 1 with class II CHF, group 2 with class III-IV CHF. In group 2 compared with group 1 before and after AS correction of AS we found the lowest level of MBF in walls of left cardiac chambers and right atrium and highest parameters of the left ventricular and atrial function according to echocardiography data. Progression of anatomic-functional changes of left ventricle at the background of AS and development of CHF is characterized by lowering of MBF volume velocity in walls of left cardiac chambers.