Treatment of joint cartilage lesions with cell therapy

• Published in: Reumatología clinica Vol. 3 Suppl 3; pp. S63 - S69
• Main Authors: Fuentes-Boquete, Isaac Manuel, Del Carmen Arufe Gonda, María, Díaz Prado, Silvia María, Hermida Gómez, Tamara, de Toro Santos, Francisco Javier, Blanco García, Francisco Javier
• Format: Journal Article
• Language: Spanish
• Published: Spain 01-10-2007
• ISSN: 1699-258X
• DOI: 10.1016/S1699-258X(07)73658-6

Articular cartilage lesions which do not affect the integrity of subchondral bone, they are not able to repair it expontaneously. The asymptomatic nature of these lesions induces articular cartilage degeneration and development of an arthrosic process. To avoid the necessity to receive joint replacement surgery, it has been developed different treatments of cellular therapy which are focused to create new tissues whose structure, biochemistry composition and function will be the same than native articular cartilage. Approaches used to access the stream produce a fibrocartilaginose tissue which is not an articular cartilage. Implantation of autologous chondrocytes and autologous mosaicplasties induces a quality better articular cartilage. Furthermore both techniques involve damage in the sane cartilage; because of trying to get a big amount of chondrocytes or because of extraction osteochondral cylinder which will be implanted in the injured joint. The stem cells are a promising toll to repair articular cartilage, however they are in a previous experimentation step yet. Although the present studies using cellular therapy improves clinically and functionally, it is not able to regenerate an articular cartilage which offer resistance the degeneration process.