Long-term follow-up 10 years after transpupillary thermotherapy (TTT) for small, posterior located malignant melanomas of the choroid

• Published in: Klinische Monatsblatter fur Augenheilkunde Vol. 228; no. 4; p. 277
• Main Authors: Stoffelns, B M, Schoepfer, K, Vetter, J, Mirshahi, A, Elflein, H
• Format: Journal Article
• Language: German
• Published: Germany 01-04-2011
• Subjects: Adult; Aged; Choroid Neoplasms - diagnosis; Choroid Neoplasms - therapy; Female; Follow-Up Studies; Humans; Hyperthermia, Induced - methods; Male; Melanoma - diagnosis; Melanoma - therapy; Middle Aged; Treatment Outcome; Young Adult
• ISSN: 1439-3999
• DOI: 10.1055/s-0031-1273207

The aim of this study was to evaluate the long-term results of transpupillary thermotherapy (TTT) for small malignant choroidal melanomas.
In the time period 1/1998 to 10/1999 in a prospective non-randomised analysis 26 eyes with small malignant melanomas (located posterior to the equator with base ≤ 12 and thickness ≤ 4.5 mm) were primary treated with the TTT standard protocol (follow-up over a time span of at least 10 years).
Thirteen women and thirteen men (mean age: 64 years) underwent TTT. The mean preoperative tumour thickness was 2.45 mm (0.8 - 4.5 mm). Ten years postoperatively tumour regression without recurrence after 1.4 treatment sessions (mean) was achieved in 16 / 26 eyes, primary regression followed by tumour regrowth in 6 / 26 eyes, and primary failure of tumour regression in 4 / 26 eyes. Two patients died on liver metastasis. Ocular complications (with preference in posterior tumours after multiple TTT sessions) were observed in 14 eyes: macular pucker in 8, macular oedema in 6, choroidal neovascularisation in 4 and posterior synechia with iris atrophy in one eye.
Choroidal melanomas treated with TTT as a stand-alone procedure need a close monitoring since these tumours developed a significant rate of local recurrences and ocular side-effects in the long run.