Changes in the system of antioxidant blood defence in newborns with different pathology

Blood antioxidant enzymes (superoxide dismutase, catalase, ceruloplasmin) were investigated in gestational ages and diseases. Low activity of blood superoxide dismutase and catalase were observed in premature babies and in newborns after acute and chronic hypoxia. In hemolytic disease the activity o...

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Bibliographic Details
Published in:	Voprosy meditsinskoi khimii Vol. 48; no. 5; p. 513
Main Authors:	Litvinenko, L A, Danilova, L A, Shabalov, N P
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-2002
Subjects:	Adolescent Adult Apgar Score Asphyxia Neonatorum - blood Asphyxia Neonatorum - therapy Blood Transfusion Catalase - blood Erythroblastosis, Fetal - blood Erythroblastosis, Fetal - therapy Gestational Age Hemoperfusion Humans Infant, Newborn Infant, Premature - blood Superoxide Dismutase - blood
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Summary:	Blood antioxidant enzymes (superoxide dismutase, catalase, ceruloplasmin) were investigated in gestational ages and diseases. Low activity of blood superoxide dismutase and catalase were observed in premature babies and in newborns after acute and chronic hypoxia. In hemolytic disease the activity of antioxidant enzymes of newborns was significantly higher than in healthy infants. This work demonstrates advantages of haemosorbtion compared to exchange blood transfusion. So the antioxidant activity in blood, decreased after blood transfusion, remained at a high level after haemosorbtion. Any deficiency of antioxidant enzymes in newborns may lead to toxyc oxygen effects. Antioxidants are potential therapeutic agents in the above mentioned conditions.
ISSN:	0042-8809