The influence of ceruloplasmin on the rat neocortical ultrastructure in circulatory hypoxia

• Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova no. Suppl 14; p. 50
• Main Authors: Smirnov, A A, Gustov, A V, Mukhina, I V, Iakovleva, E I, Korshunova, Iu A, Bugrova, M A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2005
• Subjects: Animals; Brain Ischemia - etiology; Brain Ischemia - pathology; Brain Ischemia - prevention & control; Carotid Artery, Common - surgery; Carotid Stenosis - complications; Cerebrovascular Circulation - drug effects; Ceruloplasmin - administration & dosage; Ceruloplasmin - therapeutic use; Disease Models, Animal; Injections, Intraperitoneal; Ligation; Male; Microcirculation - drug effects; Microscopy, Electron; Neocortex - blood supply; Neocortex - drug effects; Neocortex - ultrastructure; Rats; Rats, Wistar; Time Factors
• ISSN: 1997-7298

Diffuse cerebral ischemia and circulatory hypoxia were modeled by carotid arteries occlusion in 40 white Wistar male rats. The changes of microcirculation bed and neurons of the sensomotor cortical area in hypoxia, preventive and therapeutic regimes of ceruloplasmin injections were compared to the neocortex state of intact rats. The changes of the neocortical ultrastructure established by electron microscopy were characteristic of hypoxic lesions described earlier in the literature. As a result of prolonged administration of ceruloplasmin there was a significant decrease of sensomotor neocortical hypostasis and improvement of microcirculation that suggested its neuroprotective properties.