Pyridazines 91. Synthesis of substituted tri- and tetracyclic compounds bearing a pyridazine core and their biological evaluation as antimycobacterial agents

Starting from substituted 3,6-dichloropyridazine-4-carboxamides (2, 3) tri- and tetracyclic compounds (4, 5) could be smoothly prepared. Structural modifications of interest with regard to biological activity were performed by N-alkylation and reductive dehalogenation. The new substituted heterocycl...

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Bibliographic Details
Published in:	Archiv der Pharmazie (Weinheim) Vol. 333; no. 7; pp. 231 - 240
Main Authors:	Heinisch, G, Matuszczak, B, Planitzer, K
Format:	Journal Article
Language:	English
Published:	Germany 01-07-2000
Subjects:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Lipids - chemistry Lipids - pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis - drug effects Pyridazines - chemical synthesis Pyridazines - chemistry Pyridazines - pharmacology Structure-Activity Relationship
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Summary:	Starting from substituted 3,6-dichloropyridazine-4-carboxamides (2, 3) tri- and tetracyclic compounds (4, 5) could be smoothly prepared. Structural modifications of interest with regard to biological activity were performed by N-alkylation and reductive dehalogenation. The new substituted heterocyclic compounds were screened as antimycobacterial agents; the influence of the substitution pattern on activity is discussed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0365-6233