Lipid profile in maintenance haemodialysis

• Published in: Pathologie biologie (Paris) Vol. 53; no. 4; pp. 217 - 220
• Main Authors: Jamoussi, K, Ayedi, F, Abida, N, Kamoun, K, Féki, H, Chaabouni, M N, Hammouda, F, Bahloul, I, Bellaj, A, Hachicha, J, Ellouz, F
• Format: Journal Article
• Language: French
• Published: France 01-05-2005
• Subjects: Adult; Apolipoprotein A-I - blood; Apolipoproteins B - blood; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Female; Humans; Hypertriglyceridemia - etiology; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Lipids - blood; Male; Middle Aged; Renal Dialysis - adverse effects; Triglycerides - blood
• ISSN: 0369-8114
• DOI: 10.1016/j.patbio.2004.07.015

The chronic kidney failure is a source of dyslipidemia and accelerated atherosclerosis. No changes in the lipoprotein profile could be reversed by dialysis.
Our aim was to study the lipid disturbances characteristics in end stage renal disease in order to assess their theorical atherogenic potential.
The patient population consisted of 36 patients on maintenance haemodialysis. Matched control subjects were recruited among apparently healthy normolipidemic Tunisians. Total cholesterol, triglycerides, high-density-lipoprotein cholesterol, low-density-lipoprotein cholesterol, apolipoprotein AI and apolipoprotein B concentrations were measured.
The triglycerides levels were significantly higher in patient group, unlike the high-density-lipoprotein cholesterol and apolipoprotein AI levels that were significantly reduced. We saw no increase in the levels of low-density-lipoprotein cholesterol and apolipoprotein B. The low-density-lipoprotein cholesterol/high-density-lipoprotein cholesterol ratio result wasn't helpful in the evaluation of the atherogenic risk.
We confirm the quantitative lipid disorders associated with maintenance haemodialysis. The assessment of cardiovascular risk on the basis of these disorders seems difficult.