Clinical efficacy of tianeptine in patients with ischemic heart disease and comorbid depression

• Published in: Kardiologiia Vol. 44; no. 3; p. 20
• Main Authors: Pogosova, G V, Zhidko, N I, Krasnitskiĭ, V B, Tikhomirova, E A, Odintsova, A S, Akhmedzhanov, N M, Baĭchorov, I Kh
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2004
• Subjects: Adult; Aged; Antidepressive Agents, Tricyclic - administration & dosage; Antidepressive Agents, Tricyclic - therapeutic use; Cardiovascular Agents - administration & dosage; Cardiovascular Agents - therapeutic use; Depression - complications; Depression - diagnosis; Depression - drug therapy; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Ischemia - complications; Myocardial Ischemia - diagnosis; Myocardial Ischemia - drug therapy; Myocardial Ischemia - physiopathology; Quality of Life; Risk Factors; Thiazepines - administration & dosage; Thiazepines - therapeutic use; Time Factors; Treatment Outcome
• ISSN: 0022-9040

Ischemic heart disease patients (20 men, 20 women, age 36-72 years) with class II-III effort angina and depression (Beck Depression Inventory -- BDI -- score > or = 19) were randomized to standard therapy were treatment of stable ischemic heart disease (control group) or standard therapy plus tianeptine 37.5 mg/day. After 6 weeks 52% decrease of BDI score occurred in tianeptine treated patients (from 24.9+/-1.2 to 11.9+/-1.5, p<0.001). This was associated with decrease of number and severity of cardialgias, better blood pressure control in patients with hypertension, lengthening of exercise time during exercise test (by 3.3+/-0.9 min, p<0.05), and increase of overall index of quality of life (by 2.6+/-0.9 points, p<0.01). No dynamics of these parameters occurred in control group.