Syndrome of impaired tolerance to dietary fats in coronary heart disease

• Published in: Kardiologiia Vol. 43; no. 4; p. 36
• Main Authors: Bubnova, M G, Perova, N V, Aronov, D M, Olfer'ev, A M, Oganov, R G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2003
• Subjects: Adult; Aged; Apolipoproteins - blood; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Dietary Fats - administration & dosage; Humans; Hyperlipidemias - blood; Hyperlipidemias - complications; Lipoproteins, HDL - blood; Male; Middle Aged; Postprandial Period; Syndrome
• ISSN: 0022-9040

Changes of main lipid and apolipoprotein parameters of lipid transport system during postprandial hyperlipidemia were studied in subjects without (n=72) and with (n=167) overt coronary heart disease (CHD) including patients with noninsulin dependent diabetes (n=48). Tolerance to dietary fat was evaluated by oral fat load test (consumption of 639+/-7 ml of 20% cream after fast). In subjects without CHD reaction of lipid transport system to fat load was characterized by lowered total, low density lipoprotein cholesterol, apolipoprotein apo B and apo B/apo A-1 ratio, lowered or unchanged triglycerides, stable high density lipoprotein cholesterol level at the background of apo A-1 elevation by 6-th hour after load. Patients with CHD exhibited signs of impaired tolerance to dietary fat: elevation of triglycerides, apo B and apo B/apo A-1 ratio, lowering of high density lipoprotein cholesterol, increase of percentage of subfractions of small high density lipoproteins particles, increase of triglyceride content in low and high density lipoprotein fraction during 6 hours after fat load.