Role of the ETS transcription factors in the control of endothelial-specific gene expression and in angiogenesis

• Published in: Bulletin du cancer Vol. 88; no. 2; pp. 137 - 142
• Main Authors: Lelièvre, E, Lionneton, F, Soncin, F
• Format: Journal Article
• Language: French
• Published: France 01-02-2001
• Subjects: Animals; Antigens, CD; Binding Sites; Cadherins - genetics; Cadherins - physiology; Endothelium, Vascular - physiology; Gene Silencing; Humans; Neovascularization, Physiologic - genetics; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - physiology; Proto-Oncogene Proteins c-ets; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - physiology; Receptor, TIE-2; Receptors, Cell Surface - genetics; Receptors, Cell Surface - physiology; Receptors, Growth Factor - genetics; Receptors, Growth Factor - physiology; Receptors, TIE; Receptors, Vascular Endothelial Growth Factor; Transcription Factors - genetics; Transcription Factors - physiology; Vascular Endothelial Growth Factor Receptor-1
• ISSN: 0007-4551

The transcription factors of the ETS family are involved in the control of the endothelial-specific expression of genes that are important for the formation of new blood vessels. The analysis of the expression pattern of ets1, the gene inactivation of tel and fli1, the in vitro analysis of potential target genes of ETS factors in endothelial cells, the in vivo studies of the promoter regions of endothelial-specific genes all demonstrate a role for ETS factors in this specificity. However, the precise role of individual ETS factors in the endothelial identity and in angiogenesis in general remains difficult to understand in vivo.