Low-dose rate brachytherapy with locally integrated beta emitters after internal urethrotomy. A pilot project using an animal model

• Published in: Urologe. Ausgabe A Vol. 46; no. 9; pp. 1231 - 1235
• Main Authors: Weidlich, P, Adam, C, Sroka, R, Lanzl, I, Assmann, W, Stief, C
• Format: Journal Article
• Language: German
• Published: Germany 01-09-2007
• Subjects: Animals; Beta Particles - therapeutic use; Brachytherapy - methods; Catheters, Indwelling; Disease Models, Animal; Male; Phosphorus Radioisotopes - therapeutic use; Rabbits; Radiotherapy Dosage; Recurrence; Tomography, Optical Coherence; Urethra - pathology; Urethra - radiation effects; Urethral Stricture - pathology; Urethral Stricture - radiotherapy
• ISSN: 0340-2592
• DOI: 10.1007/s00120-007-1386-6

The treatment of urethral strictures represents an unsolved urological problem.
The effect of a (32)P-coated urethral catheter in the sense of low-dose rate brachytherapy to modulate wound healing will be analyzed in an animal experiment.
Unfortunately it is not possible to present any results because this is being studied for the first time and there are no experiences with low-dose rate brachytherapy and this form of application in the lower urinary tract. Furthermore the animal experiment will only start in the near future. Both decade-long experiences with radiotherapy to treat benign diseases and our own results of previous studies in otolaryngology and ophthalmology let us expect a significantly lower formation of urethral strictures after internal urethrotomy.
This study will contribute to improving the treatment of urethral strictures as demanded in previous papers.