Synthesis and antigenic activity of peptides from core- and NS3-proteins of hepatitis C virus

We synthesized the 20-34 and 22-34 fragments of the core and 1269-1282 fragment of the NS3 protein of the hepatitis C virus. The peptides were prepared by the solid-phase synthesis using activated esters and symmetrical anhydrides of Boc-amino acids. Peptide 20-34 demonstrated positive reaction in E...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 19; no. 1; p. 126
Main Authors:	Semiletov, Iu A, Firsova, T V, Shibnev, V A, Viazov, S O
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1993
Subjects:	Amino Acid Sequence Antigens, Viral - immunology Hepacivirus - chemistry Molecular Sequence Data Peptide Fragments - chemical synthesis Peptide Fragments - immunology Viral Core Proteins - chemistry Viral Nonstructural Proteins - chemistry
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Summary:	We synthesized the 20-34 and 22-34 fragments of the core and 1269-1282 fragment of the NS3 protein of the hepatitis C virus. The peptides were prepared by the solid-phase synthesis using activated esters and symmetrical anhydrides of Boc-amino acids. Peptide 20-34 demonstrated positive reaction in ELISA with all individual sera from HCV chronic patients. Peptide 1269-1282 reacted with 33% patients sera.
ISSN:	0132-3423