The effect of cardioactive drugs on the proteolytic activity of the rat heart muscle

Cardioactive drugs--beta-adrenoblocking agents (propranolol, trasicor and cordanum) and Ca2(+)-antagonists (nifedipine and phenoptine)--exhibited both activating and inhibitory effects on proteolytic activity in rat heart tissue extract. The beta-adrenoblocking agents did not affect distinctly the a...

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Bibliographic Details
Published in:	Voprosy meditsinskoi khimii Vol. 36; no. 3; p. 54
Main Authors:	Karapetian, R G, Akopian, T N, Oganisian, A I, Oganesian, S S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-1990
Subjects:	Adrenergic beta-Antagonists - pharmacology Animals Calcium Channel Blockers - pharmacology Cardiotonic Agents - pharmacology Heart - drug effects Hydrogen-Ion Concentration Hydrolysis In Vitro Techniques Male Myocardium - enzymology Peptide Hydrolases - metabolism Rats Tissue Extracts - metabolism
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Summary:	Cardioactive drugs--beta-adrenoblocking agents (propranolol, trasicor and cordanum) and Ca2(+)-antagonists (nifedipine and phenoptine)--exhibited both activating and inhibitory effects on proteolytic activity in rat heart tissue extract. The beta-adrenoblocking agents did not affect distinctly the activity of partially purified cathepsin D and Ca2(+)-dependent neutral protease from myocardium. Nifedipine inhibited cathepsin D by 50% and Ca2(+-dependent neutral protease--by 75%; phenoptine inhibited also the latter enzyme by 30%.
ISSN:	0042-8809