Synthesis and antigenic activity of peptides from the ORF3 protein sequence of hepatitis E virus

The hepatitis E virus (HEV) is an infection agent (detected recently) responsible for an enterically transmitted non-A, non-B hepatitis [1,2]. Hepatitis E is a big problem in many developing countries, including the Central Asian areas of the former Soviet Union [2]. By cloning followed by sequence...

Full description

Saved in:

Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 21; no. 2; p. 156
Main Authors:	Semiletov, Iu A, Dement'evaEV, Iashina, T L, Favorov, M O, Shibnev, V A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-02-1995
Subjects:	Amino Acid Sequence Antigens, Viral - immunology Base Sequence Hepatitis E virus - chemistry Hepatitis E virus - genetics Molecular Sequence Data Open Reading Frames Peptide Fragments - genetics Peptide Fragments - immunology Viral Proteins - genetics
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The hepatitis E virus (HEV) is an infection agent (detected recently) responsible for an enterically transmitted non-A, non-B hepatitis [1,2]. Hepatitis E is a big problem in many developing countries, including the Central Asian areas of the former Soviet Union [2]. By cloning followed by sequence analysis of the HEV genome, three open reading frames (ORF) have been identified, among them ORF3 encoding a protein containing 123 amino acid residues, the function of this protein being unknown. Recently [3], one of the immunodominant regions of ORF3 protein was revealed between the 91st and 123rd amino acid residue. The purpose of the present study was a more precise localization of epitopes in the C-terminal portion of HEV ORF3 protein by using synthetic peptides.
ISSN:	0132-3423