Treatment of experimental genital herpes with liposomal interferon

• Published in: Vestnik Akademii meditsinskikh nauk SSSR no. 8; p. 35
• Main Authors: Mel'nikov, V R, Kobrinskiĭ, G D, L'vov, N D, Bolotin, I M, Barinskiĭ, I F
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1990
• Subjects: Administration, Cutaneous; Animals; Balanitis - drug therapy; Disease Models, Animal; Drug Carriers; Drug Evaluation, Preclinical; Guinea Pigs; Herpes Genitalis - drug therapy; Interferon Type I - administration & dosage; Interferon-alpha; Liposomes - therapeutic use; Male; Recombinant Proteins
• ISSN: 0002-3027

Treatment of genital herpes was studied in experiments on male guinea pigs infected with herpes simplex II virus in suspension, by means of the penis skin scarification. The medication was provided by interferon (reaferon) prepared by the technique was provided by interferon (reaferon) prepared by the technique of genetic engineering, and incorporated into liposomes composed of phosphatidyl choline and cholesterol (molar ratio, 1:1). Free or liposome-contained interferon solutions, either mixed with hydrocolloidal substance or pure, were applied to the affected site of the animals' genitalia three times daily. The severity of clinical symptoms and disease duration were used as markers of preparation efficacy. The obtained results showed the liposomal interferon preparations to be most effective irrespective of being mixed with the hydrocolloidal substance or pure. Free interferon solutions demonstrated the lowest therapeutic efficacy, while the effect of hydrocolloidal interferon was found to be median. Experimental use of such antiviral preparations as BIOLF-62 and acyclovir as a medication against genital herpes also showed the advantages of the liposomal drug forms over free solutions.