"Dynamic" component of carotid artery stenosis in patients with cerebrovascular disorders

Nifedipine is shown to abolish contraction of the vessel at the site of the internal carotid artery stenosis induced by a cold test. It can furthermore produce a direct 5-40% reduction of the stenosis, the effect being dependent both on the drug plasma level and the ability to rise such levels of pr...

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Bibliographic Details
Published in:	Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) Vol. 91; no. 1; p. 44
Main Authors:	Gabrielian, E S, Akopov, S E, Grigorian, G S, Tunian, Iu S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1991
Subjects:	Adult Aged Brain - blood supply Brain Ischemia - drug therapy Brain Ischemia - etiology Brain Ischemia - physiopathology Carotid Artery Diseases - complications Carotid Artery Diseases - drug therapy Carotid Artery, Internal - drug effects Carotid Artery, Internal - physiopathology Humans Middle Aged Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Nifedipine - therapeutic use Spasm - complications Spasm - drug therapy Spasm - physiopathology Vascular Patency - drug effects Vascular Patency - physiology
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Summary:	Nifedipine is shown to abolish contraction of the vessel at the site of the internal carotid artery stenosis induced by a cold test. It can furthermore produce a direct 5-40% reduction of the stenosis, the effect being dependent both on the drug plasma level and the ability to rise such levels of prostacyclin. In some patients there is a possibility of nifedipine contrary action when it promotes stenosis (up to 5-30% increase) and leads to disturbances of cerebral circulation. Consequently, to make optimal therapeutic measures in relevant patients nifedipine should be tried for stenosis-directed action.
ISSN:	0044-4588