Synthesis and properties of 7-hydroxyalkyl-8-benzylaminotheophyllines

The synthetic routes leading to 7-beta-hydroxyethyl- (I) and 7-beta-hydroxypropyl-8-benzylaminotheophylline (II) were described. Particularly the opening of oxazolidine ring in easy available oxazolidine-(2,3-f)-theophyllines with benzylamine was investigated. The structure of I, II and acetyl deriv...

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Bibliographic Details
Published in:	Polish journal of pharmacology and pharmacy Vol. 27; no. 3; p. 305
Main Authors:	Gorczyca, M, Pawlowski, M, Ryznerski, Z
Format:	Journal Article
Language:	English
Published:	Poland 01-05-1975
Subjects:	Animals Lethal Dose 50 Mice Spectrophotometry, Ultraviolet Theophylline - analogs & derivatives Theophylline - chemical synthesis Theophylline - toxicity
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Summary:	The synthetic routes leading to 7-beta-hydroxyethyl- (I) and 7-beta-hydroxypropyl-8-benzylaminotheophylline (II) were described. Particularly the opening of oxazolidine ring in easy available oxazolidine-(2,3-f)-theophyllines with benzylamine was investigated. The structure of I, II and acetyl derivatives Ia, Ib, IIa and IIb was also confirmed by UV spectra.
ISSN:	0301-0244