Analysis of oxidative stress in Wistar rats submitted to high-intensity interval training

• Published in: Motricidade Vol. 16; no. 3; pp. 174 - 181
• Main Authors: Souza, Lúcio Marques Vieira, Aidar, Felipe José, de Matos, Dihogo Gama, Marçal, Anderson Carlos, de Souza, Raphael Fabricio, dos Santos, Jymmys Lopes, Wartha, Elma Regina Silva de Andrade, da Silva, Albená Nunes, Estevam, Charles dos Santos, de Araújo, Silvan Silva
• Format: Journal Article
• Language: English; Portuguese
• Published: Ribeira de Pena Edições Desafio Singular 30-09-2020
• Subjects: Adaptation; Animals; Antioxidants; Exercise; Interval training; Liver; Oxidative stress; Physiology; Plasma; SPORT SCIENCES; Uric acid; Brazil; High-intensity interval training; swimming; oxidative stress
• ISSN: 1646-107X; 2182-2972
• DOI: 10.6063/motricidade.21310

Physical exercise is a known factor that can promote oxidative stress and may result in cellular damage if not neutralized by antioxidant mechanisms. This study aimed to determine if the level of hepatic oxidative stress resulting from high-intensity interval training (HIIT) is affected by the frequency pattern (consecutive vs. non-consecutive) of the training sessions. Thirty-two Wistar rats were divided equally into four groups: two control groups, (CS1) and (CS2), remained sedentary throughout the experiment, and two test groups, (CT1) and (CT2), and were submitted to HIIT for 12 consecutive and non-consecutive (12 sessions, 3 times/wk over four weeks) days, respectively. There were no significant differences in markers of oxidative damage measured in hepatic tissue (TBARS) and markers of antioxidant activity (Sulfhydryl, FRAP), as well as markers of hepatic damage (AST and ALT) and antioxidant defense (Uric Acid) measured in plasma of both HIIT groups after training compared to the control groups. The results indicate that both HIIT performed for 12 consecutive and non-consecutive sessions did not promote hepatic oxidative damage in rats.