Effect of papaverine on H+ transport in suspension of cat brain mitochondria

The intravenous administration of papaverin (3 mg/kg) under conditions of acute experiments showed that it is able to induce a considerable increase in intensity of H+ release from mitochondria of the cat brain tissue cells. Taking into consideration the data of previous researches testifying to the...

Full description

Saved in:

Bibliographic Details
Published in:	Ukrainskij biohimičeskij žurnal Vol. 50; no. 5; p. 567
Main Authors:	Mkheian, E E, Gabrielian, E S, Sotskii, O P, Amroian, E A
Format:	Journal Article
Language:	Russian
Published:	Ukraine 01-09-1978
Subjects:	Animals Biological Transport, Active - drug effects Brain - drug effects Brain - metabolism Cats Female Hydrogen-Ion Concentration Mitochondria - drug effects Mitochondria - metabolism Papaverine - pharmacology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The intravenous administration of papaverin (3 mg/kg) under conditions of acute experiments showed that it is able to induce a considerable increase in intensity of H+ release from mitochondria of the cat brain tissue cells. Taking into consideration the data of previous researches testifying to the fact taht under the papaverine influence there occurs H+ accumulation in cells due to metabolism intensification, it may be suppose that an intensified release of H+ from the mitochondria plays a definite role in vasodilation of the brain by stimulation of the vessels H+-sensitive receptors.
ISSN:	0201-8470