Prognostic significance of the number of dissected lymph nodes in Siewert type Ⅱadenocarcinoma of the esophagogastric junction without lymphatic metastasis

• Published in: Zhōnghuá zhŏngliú zázhì Vol. 38; no. 4; p. 300
• Main Authors: Wang, J Q, Wei, D Z, Xie, M R, Xu, S B, Ma, D C
• Format: Journal Article
• Language: Chinese
• Published: China 01-04-2016
• Subjects: Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophagectomy; Esophagogastric Junction - surgery; Gastrectomy; Humans; Lymph Node Excision; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic Metastasis; Prognosis; Retrospective Studies; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Survival Rate
• ISSN: 0253-3766
• DOI: 10.3760/cma.j.issn.0253-3766.2016.04.011

To investigate the correlation between the number of dissected lymph nodes (LNs) and the prognosis of patients with node-negative Siewert type ⅡAEG.
248 patients with Siewert type Ⅱ AEG treated in our hospital between January 1998 and December 2008 were retrospectively assessed. All cases underwent left transthoracic subtotal esophagogastrectomy with conventional two-field lymphadenectomy, and were histopathologically proved to be without lymph node involvement. The prognostic impact of the number of dissected LNs was analyzed.
The overall median survival time and the 1-, 3-, and 5-year overall survival rates were 64 months, 80.4%, 60.8% and 51.0%, respectively. Cox regression showed that the number of dissected LNs and the depth of tumor invasion were independent prognostic factors. Patients with a high number of negative LNs had better overall survival than patients with a low number of negative LNs (P<0.05). The patients had better long-term survival outcomes with more than 10 LN dissected for cases with p