Twenty-Five Cases of Locally Advanced Rectal Cancer That Underwent Laparoscopic Surgery after Preoperative Chemotherapy

• Published in: Gan to kagaku ryoho Vol. 44; no. 12; p. 1772
• Main Authors: Okuda, Hiroshi, Nakahara, Masahiro, Yano, Takuya, Bekki, Tomoaki, Takechi, Hitomi, Yoshikawa, Toru, Mochizuki, Tetsuya, Abe, Tomoyuki, Fujikuni, Nobuaki, Sasada, Tatsunari, Yamaki, Minoru, Amano, Hironobu, Noriyuki, Toshio
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-11-2017
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Combined Modality Therapy; Female; Humans; Laparoscopy; Male; Middle Aged; Postoperative Complications; Rectal Neoplasms - drug therapy; Rectal Neoplasms - surgery; Treatment Outcome
• ISSN: 0385-0684

Several recent reports have described the administration of preoperative chemotherapy for locally advanced rectal cancer. In our hospital, preoperative chemotherapy based on oxaliplatin was administered for locally advanced rectal cancer with a tumor diameter of 5 cm or more and half semicircularity or more, and curative resection with laparoscopic surgery was performed after tumor shrinkage. We have experienced 25 cases that underwent preoperative chemotherapy for local advanced rectal cancer in our hospital from May 2012 to April 2016. No tumor increased in size during preoperative chemotherapy and there were no cases where R0 resection was impossible. In addition, no distant metastasis during chemotherapy was observed. Postoperative complications were observed in 3 cases(12%), and anastomotic leakage was observed in 1 case (4%), but conservative treatment was possible. Multidisciplinary treatment of preoperative chemotherapy and surgery should be considered as a therapeutic strategy for locally advanced rectal cancer, mainly in medical institutions without radiation treatment facilities.