Application and evaluation of invasive prenatal diagnostic techniques and analysis of chromosomal karyotype

• Published in: Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 38; no. 4; p. 400
• Main Authors: Wang, Liqiong, Wang, Xin, Zhang, Shaoling, Zhou, Zhongmin, Zhu, Fufan, Ding, Yiling
• Format: Journal Article
• Language: Chinese
• Published: China 01-04-2013
• Subjects: Abnormal Karyotype - statistics & numerical data; Adult; Amniocentesis - methods; Cordocentesis - adverse effects; Cordocentesis - methods; Evaluation Studies as Topic; Female; Humans; Karyotyping - methods; Pregnancy; Prenatal Diagnosis - methods; Retrospective Studies
• ISSN: 1672-7347
• DOI: 10.3969/j.issn.1672-7347.2013.04.011

To evaluate the safety, effectiveness and complications of serial invasive prenatal diagnostic techniques, and to investigate the prenatal diagnosis indication as well as to analyze the abnormal chromosomal karyotype.
We retrospectively studied all patients from March 2005 to May 2012 who received amniocentesis and cordocentesis in the prenatal diagnosis center of Second Xiangya Hospital. The indication of the procedure, successful rate and complications were evaluated, and 25 abnormal chromosome nuclear types were analyzed.
A total of 669 patients received invasive prenatal diagnosis from March 2005 to May 2012 in Second Xiangya Hospital: 598 received amniocentesis and 71 cordocentesis carried out. Compared with the cordocentesis group, the amniocentesis group had higher achievement ratio (91.54% vs 100%, P<0.05), lower spontaneous abortion rate (1.41% vs 0.33%, P<0.05), fewer abnormal karyotypes (11.27% vs 2.84%, P<0.05) and lower expenditure (880 yuan vs 800 yuan, P<0.05). Positive screening, advanced mate