Unicentric Castleman's disease: an uncommon cause of chronic cough

• Published in: Tunisie Medicale Vol. 96; no. 2; p. 148
• Main Authors: Bacha, Saoussen, Zribi, Hazem, Habibech, Sonia, Attia, Monia, Ayadi, Aida, Mezni, Faouzi, Chabbou, Abdellatif
• Format: Journal Article
• Language: English
• Published: Tunisia 01-02-2018
• Subjects: Castleman Disease - complications; Castleman Disease - diagnosis; Chronic Disease; Cough - diagnosis; Cough - etiology; Diagnosis, Differential; Female; Humans; Middle Aged
• ISSN: 0041-4131

Castleman disease (CD) or angiofollicular lymph node hyperplasia is a rare lymphoproliferative disorder characterized by lymph node hyperplasia of uncertain etiology. CD is divided clinically into unicentric (localized to one region of the body) considered as a benign disease and multicentric with less favourable prognosis. We describe a case of intrathoracic unicentric CD revealed by a chronic non-productive cough in a 50-year-old non-smoker female. Chest computed tomography revealed a bulky right hilar mass with intense homogenous contrast enhancement. The patient underwent a right upper lobectomy and mediastinal lymphadenectomy. Histopathology was consistent with hyaline-vascular (HV) type CD. The patient remained asymptomatic throughout the subsequent 6-months of follow-up.