Evaluation of peripheral neuropathy in the patients with type 2 diabetes mellitus by laboratory examination: relationship between albuminuria and ankle-brachial index

• Published in: Rinsho byori. The Japanese journal of clinical pathology Vol. 62; no. 6; p. 538
• Main Authors: Hirose, Ayumi, Watanabe, Tsuneo, Nabetani, Yosuke, Nohisa, Yuzuru, Furuta, Nobuyuki, Kawachi, Shin-ichi, Ito, Hiroyasu, Matsuoka, Toshio, Seishima, Mitsuru
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-06-2014
• Subjects: Albuminuria - complications; Ankle Brachial Index; Diabetes Mellitus, Type 2 - complications; Diabetic Angiopathies - etiology; Diabetic Angiopathies - physiopathology; Female; Humans; Male; Middle Aged
• ISSN: 0047-1860

The aim of this study was to investigate the influence of peripheral neuropathy on laboratory examinations and to evaluate the relationship between nerve conduction velocity (NCV), albuminuria, and ankle-brachial index (ABI) results in patients with type 2 diabetes mellitus (DM). One hundred twenty-six patients with type 2 DM who had undertaken the nerve conduction study for an initial screening test of diabetic complications were included in our study. We divided patients to 4 groups according to the stage of microalbuminuria and ABI results. Two factors negative (2FN) group (n = 75), urinary albumin creatinine ratio (A/C) < 30 mg/gCr and ABI > or = 1.0; A/C group (n = 25), A/C > or = 30 mg/gCr and ABI > or = 1.0; ABI group (n = 14), A/C < 30 mg/gCr and ABI < 1.0; two factors positive (2FP) group (n = 12), A/C > or = 30 mg/gCr and ABI < 1.0. Neuropathy, retinopathy, hypertension, macroangiopathy, and hyperlipidemia were seen in 57.9%, 38.1%, 59.5%, 22.2%, and 56.3%, respectively. Lower leg NCV in 2FP group was significantly lower than other groups. Our study indicated that impaired diabetic peripheral neuropathy may be detected by combining decreased ABI with increased A/C results.