Recurrent pregnancy loss

Recurrent pregnancy loss (RPL) is defined as three or more consecutive pregnancy losses, and it affects 2-3% of couples trying to conceive. RPL is a multifactorial disorder, and only few evidence-based treatments are available. It is associated with an increased prevalence of stress and major depres...

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Bibliographic Details
Published in:	Ugeskrift for læger Vol. 179; no. 17
Main Authors:	Krog, Maria Christine, Kolte, Astrid Marie, Husby, Karen, Egerup, Pia, Larsen, Elisabeth Clare, Christiansen, Ole Bjarne, Nielsen, Henriette Svarre
Format:	Journal Article
Language:	Danish
Published:	Denmark 24-04-2017
Subjects:	Abortion, Habitual - diagnosis Abortion, Habitual - immunology Biomarkers - analysis Female Histocompatibility Antigens Class II - immunology HLA-A Antigens - immunology HLA-DRB1 Chains - immunology Humans Pregnancy Risk Factors T-Lymphocytes, Regulatory - immunology Th17 Cells - immunology
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Summary:	Recurrent pregnancy loss (RPL) is defined as three or more consecutive pregnancy losses, and it affects 2-3% of couples trying to conceive. RPL is a multifactorial disorder, and only few evidence-based treatments are available. It is associated with an increased prevalence of stress and major depression, and also with immunogenetic markers, autoimmunity and an increase of the risk of cardiovascular disease in later life. Immunology seems to be a key element in RPL, and further research is needed to understand the pathogenesis of this heterogeneous condition in order to develop personalized treatment.
ISSN:	1603-6824