Interstitial pneumonitis after treatment for hepatitis C virus infection

Pulmonary toxicity is a rare side effect of interferon treatment with a wide spectrum of lung tissue conditions, including interstitial pneumonitis, pulmonary sarcoidosis, bronchiolitis obliterans organizing pneumonia, pleural effusion, exacerbation of bronchial asthma, reversible pulmonary hyperten...

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Bibliographic Details
Published in:	Pneumologia (Bucharest, Romania) Vol. 64; no. 1; p. 46
Main Authors:	Botnaru, Victor, Munteanu, Oxana, Rusu, Doina
Format:	Journal Article
Language:	English
Published:	Romania 01-01-2015
Subjects:	Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Disease Progression Female Glucocorticoids - administration & dosage Glucocorticoids - therapeutic use Hepatitis C, Chronic - drug therapy Humans Interferon-alpha - administration & dosage Interferon-alpha - adverse effects Lung Diseases, Interstitial - chemically induced Lung Diseases, Interstitial - diagnosis Lung Diseases, Interstitial - drug therapy Middle Aged Polyethylene Glycols - administration & dosage Polyethylene Glycols - adverse effects Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects Ribavirin - administration & dosage Time Factors Treatment Outcome
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Summary:	Pulmonary toxicity is a rare side effect of interferon treatment with a wide spectrum of lung tissue conditions, including interstitial pneumonitis, pulmonary sarcoidosis, bronchiolitis obliterans organizing pneumonia, pleural effusion, exacerbation of bronchial asthma, reversible pulmonary hypertension and acute respiratory distress syndrome. We report a case of interstitial pneumonitis in a patient treated with pegylated interferon α2-a and ribavirin for chronic hepatitis C virus infection, genotype 1. The case was marked by progression of the respiratory symptoms even after the withdrawn of the pegylated interferon. One-year treatment with systemic corticosteroid ensured a considerable resorption of CT lesions but only a moderate improvement of symptoms and diffusion capacity without a complete recovery.
ISSN:	2067-2993