Clinical Research Progress on Transformed Lymphoma -Review

Histologic transformation (HT) is a frequent event in the clinical course of patients with indolent lymphoma with dismal outcome. The diagnosis of HT is based on clinical manifestation, PET-CT and pathologic biopsy, and the latter is a golden standard for HT. There are contradictory data about the i...

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Bibliographic Details
Published in:	Zhongguo shi yan xue ye xue za zhi Vol. 24; no. 4; p. 1232
Main Authors:	Wang, Bing-Jie, Cen, Xi-Nan, Ren, Han-Yun
Format:	Journal Article
Language:	Chinese
Published:	China 01-08-2016
Subjects:	Antineoplastic Combined Chemotherapy Protocols Humans Lymphoma, Non-Hodgkin
Online Access:	Get more information
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Summary:	Histologic transformation (HT) is a frequent event in the clinical course of patients with indolent lymphoma with dismal outcome. The diagnosis of HT is based on clinical manifestation, PET-CT and pathologic biopsy, and the latter is a golden standard for HT. There are contradictory data about the impact of initial management on the risk of transformation. Patients who present with HT did not receive R-CHOP or chemotherapy-naive, should receive this regimen. For the subset of patients received R-CHOP prior to HT, the second line chemotherapy for DLBCL should be adopted. Consolidation with HDT-ASCT should be considered for the suitable young patients. The radio-immunotherapy and novel drugs showed a bright perspective for the patients with HT.
ISSN:	1009-2137
DOI:	10.7534/j.issn.1009-2137.2016.04.050