Elevated serum resistin in juvenile idiopathic arthritis: relation to categories and disease activity

• Published in: Journal of clinical immunology Vol. 33; no. 1; pp. 297 - 301
• Main Authors: Gheita, Tamer A, El-Gazzar, Iman I, El Shazly, Reem I, El-Din, Abeer M Nour, Abdel-Rasheed, Enas, Bassyouni, Rasha H
• Format: Journal Article
• Language: English
• Published: Netherlands 01-01-2013
• Subjects: Adolescent; Antibodies, Antinuclear - biosynthesis; Antibodies, Antinuclear - blood; Arthritis, Juvenile - classification; Arthritis, Juvenile - diagnosis; Arthritis, Juvenile - immunology; Biomarkers - blood; Child; Female; Humans; Male; Resistin - biosynthesis; Resistin - blood; Rheumatoid Factor - biosynthesis; Rheumatoid Factor - blood; Up-Regulation - immunology
• ISSN: 1573-2592
• DOI: 10.1007/s10875-012-9760-6

Juvenile Idiopathic Arthritis (JIA) is one of the more common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity, including physical disability. The aim of the present study was to assess the serum level of resistin in JIA patients and compare its levels according to the categories, clinical manifestations and disease activity.
Sixty-eight JIA patients and 33 age and sex matched control children were included in the present study. All patients included in this study were subjected to full history taking, clinical examination. Juvenile arthritis disease activity score in 27 joints (JADAS-27) was calculated and Childhood Health Assessment Questionnaire (CHAQ) was used to measure the functional status. Serum resistin levels were measured by enzyme-linked immunosorbent assay (ELISA).
The mean serum resistin was significantly higher in the JIA patients (4.01 ± 2.46 ng/ml) compared to the control (2.08 ± 1.23 ng/ml) (p<0.001) especially those with systemic-onset. Its level was significantly higher in those receiving steroids and those with a positive antinuclear antibody. Resistin significantly correlated with the JADAS27 (r 0.26, p 0.035) and CHAQ (r 0.4, p 0.001). The JIA patients were 50 females and 18 males; however, the level of resistin was insignificantly different according to the gender although there was a tendency to be higher in females.
Our results reinforce the proposition of an important role for resistin in JIA and may be considered an interesting biomarker for disease activity especially those with systemic onset.