A nested case-control study on the association of neonatal cord blood selenium, iron and copper with congenital heart disease

• Published in: Zhōnghuá yùfáng-yīxué zázhì Vol. 57; no. 2; p. 200
• Main Authors: Liu, Q, Mao, B H, Li, J H, Wang, W D, Du, S H, Yi, B
• Format: Journal Article
• Language: Chinese
• Published: China 06-02-2023
• Subjects: Case-Control Studies; Copper - analysis; Fetal Blood - chemistry; Heart Defects, Congenital; Humans; Infant, Newborn; Iron - analysis; Selenium
• ISSN: 0253-9624
• DOI: 10.3760/cma.j.cn112150-20220518-00500

To investigate the relationship between the levels of selenium, iron and copper in cord blood of neonates and the risk of congenital heart disease (CHD), and analyze their interaction effects.
The subjects were obtained from the birth cohort in Lanzhou area established from 2010 to 2012. A baseline survey was conducted in the first trimester, and the follow-up was conducted in the second trimester, third trimester and 42 days after delivery. The umbilical vein blood was collected from newborns at delivery, and information on their birth outcomes was extracted from medical records. A nested case-control study was used to select 97 neonates with CHD newly diagnosed by echocardiography as the case group, and 194 neonates were selected as the control group by 1∶2 matching according to their mother's age, block and CHD onset time. Inductively coupled ion mass spectrometry was used to detect the concentrations of selenium, iron and copper in neonatal cord blood. The element exposure was categorized into three group