The relationship between EGFR mutation and clinico-pathological features of lung adenocarcinoma in residents of southern Russia

• Published in: Klinicheskaia meditsina Vol. 92; no. 7; p. 57
• Main Authors: Vodolazhskiĭ, D I, Kit, O I, Maksimov, A Iu, Antonets, A V, Dvadnenko, K V, Vladimirova, L Iu, Leĭman, I A, Lazutin, Iu N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2014
• Subjects: Adenocarcinoma - epidemiology; Adenocarcinoma - genetics; Adenocarcinoma - pathology; Carcinoma, Non-Small-Cell Lung - epidemiology; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; DNA Mutational Analysis; Female; Gene Frequency; Humans; Lung - pathology; Lung Neoplasms - epidemiology; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Middle Aged; Mutation; Neoplasm Staging; Receptor, Epidermal Growth Factor - genetics; Risk Factors; Russia - epidemiology; Sex Factors; Smoking - adverse effects; Statistics as Topic; Russia
• ISSN: 0023-2149

The study was designed to analyse the relationship between EGFR mutation and clinico-pathological features of lung adenocarcinoma in residents of southern Russia taking account oftheir age and sex, localization of the primary tumour, its cell differentiation, regional metastases, stage of disease and smoking status of the patients with mutant and wild-type EGFR genes. The frequency analysis included 29 somatic mutations in EGFR exones 18-21. The study revealed statistically significant associations of EGFR gene mutations with gender, smoking and stage of disease.