Dynamics of microrheologic properties of erythrocytes in patients with arterial hypertension and dyslipidemia treated with atorvastatin

• Published in: Klinicheskaia meditsina Vol. 90; no. 6; p. 42
• Main Authors: Medvedev, I N, Skoriatina, I A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2012
• Subjects: Anticholesteremic Agents - pharmacology; Atorvastatin Calcium; Comorbidity; Dyslipidemias - blood; Dyslipidemias - drug therapy; Dyslipidemias - epidemiology; Erythrocytes - cytology; Erythrocytes - drug effects; Heptanoic Acids - pharmacology; Humans; Hypertension - blood; Hypertension - drug therapy; Hypertension - epidemiology; Middle Aged; Pyrroles - pharmacology; Rheology - methods; Severity of Illness Index
• ISSN: 0023-2149

The aim of this work was to study the influence of atorvastatin, hydroxymethylglutaryl coenzyme A reductase inhibitor, on microrheologic properties of erythrocytes in patients with arterial hypertension and dyslipidemia. 33 patients (mean age 52.8+-1.7 years) having grade I-II AH with type IIb dyslipidemia, risk 3 (DAGZ criteria. 2008) were compared with 26 age-matched healthy subjects. Atorvastatin therapy optimized blood lipid spectrum, lipid peroxidation, and lipid composition of erythrocyte membranes within 16 weeks after the onset. It decreased activated lipid peroxidation in erythrocytes due to enhanced antioxidant protection. The blood diskocyte level was normalized within 16 weeks of therapy. Simultaneously, the total number of reversibly and irreversibly altered erythrocytes decreased to the stable normal level. The total number and size of erythrocytes in an aggregate were also close to those in healthy subjects while the amount of unbound cells increased.