Liver damage in automotive and industrial workers of the glass

• Published in: Annali di igiene Vol. 26; no. 2; p. 148
• Main Authors: Sancini, A, Casale, T, De Sio, S, Rosati, M V, Sacco, C, Montuori, L, Nardone, N, Giubilati, R, Iannattone, G, Nieto, H A, Bonomi, S, Tomei, G, Tomei, F, Caciari, T
• Format: Journal Article
• Language: English
• Published: Italy 01-03-2014
• Subjects: Adult; Alanine Transaminase - blood; Alcohol Drinking - adverse effects; Antioxidants - metabolism; Aspartate Aminotransferases - blood; Bilirubin - blood; Biomarkers - blood; Case-Control Studies; Chemical and Drug Induced Liver Injury - blood; Chemical and Drug Induced Liver Injury - diagnosis; gamma-Glutamyltransferase - blood; Glass; Humans; Male; Manufactured Materials - adverse effects; Middle Aged; Occupational Exposure - adverse effects; Risk Factors; Smoking - adverse effects; Solvents - adverse effects
• ISSN: 1120-9135
• DOI: 10.7416/ai.2014.1970

High doses of organic solvents can cause hepatic disease. We investigated whether exposure to low doses of solvents in automotive and industrial workers may lead to changes in liver tests.
We studied the liver parameters (glutamic oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), gamma-glutamyl-traspeptidasi (γ-GT), alkaline phosphatase (PHA), total (TB) and direct bilirubin (DB) of 24 workers exposed to organic solvents and of 30 unexposed controls.
A significant increase of GOT, GPT and γ-GT was found in exposed workers compared to unexposed controls workers. The ratio GPT/GOT was significantly higher among the exposed compared to controls.
The results confirmed the hypothesis that exposure to low doses of solvents may determine a liver damage.