Clinical analysis of 49 cases of esthesioneuroblastoma

• Published in: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Vol. 49; no. 3; p. 210
• Main Authors: Mao, Mingfeng, Wang, Rongguang, Wang, Hongtian, Zhang, Xinxin, Chen, Lei
• Format: Journal Article
• Language: Chinese
• Published: China 01-03-2014
• Subjects: Adolescent; Adult; Aged; Combined Modality Therapy; Esthesioneuroblastoma, Olfactory - diagnosis; Esthesioneuroblastoma, Olfactory - therapy; Female; Humans; Male; Middle Aged; Nasal Cavity; Nose Neoplasms - diagnosis; Nose Neoplasms - therapy; Prognosis; Retrospective Studies; Young Adult
• ISSN: 1673-0860

To investigate the optimal treatment and prognostic factors of esthesioneuroblastoma (ENB).
Forty-nine cases of ENB, received therapies in Chinese people liberation army general hospital from October 2004 to June 2013, were reviewed retrospectively. The therapeutical strategies and prognostic factors were analyzed using the Kaplan-Meier method. Efficacy of different therapeutical strategies was compared.
The 5-year overall survival (OS) in the group was 63.8%. The 5-year OS of Kadish stage A, B, C were 90.0%, 77.1%, 32.6%, respectively, with significant difference (χ(2) = 7.379, P = 0.03). The 5-year OS of the patients treated by surgery and radiotherapy, chemoradiotherapy, surgery with chemoradiotherapy were 68.6%, 0, 92.3%, respectively, with significant difference (χ(2) = 8.140, P = 0.02). The 5-year OS of the patients with transnasal endoscopic resection (or combined with transcranial resection) and lateral rhinotomy ( or combined with transcranial resection) were 63.7%, 50.0%, respectively, which had no