The aggregation capacity of neutrophils in patients with arterial hypertension and dyslipidemia treated with fluvastatin

• Published in: Klinicheskaia meditsina Vol. 93; no. 1; p. 66
• Main Authors: Medvedev, I N, Skoryatina, I A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2015
• Subjects: Cell Aggregation - drug effects; Dyslipidemias - drug therapy; Fatty Acids, Monounsaturated - administration & dosage; Fatty Acids, Monounsaturated - pharmacology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hypertension - drug therapy; Indoles - administration & dosage; Indoles - pharmacology; Middle Aged; Neutrophils - drug effects; Treatment Outcome
• ISSN: 0023-2149

To elucidate the aggregation capacity of neutrophils in patients with arterial hypertension and dyslipidemia treated with fluvastatin.
32 middle-aged patients with grade 1-2 AH and dyslipidemia (risk 3). Control group included 26 age-matched healthy subjects. We estimated lipid composition, antioxidant protection, lipid peroxidation in plasma and neutrophils and their aggregation. All patients were given 40 mg fluvastatin at bedtime. Clinical and laboratory characteristics were evaluated before and 4, 16, 52 weeks after treatment. The results were treated by the Student's t-test.
The patients showed enhanced neutrophil aggregation due to lipid imbalance in cell membranes, intense lipid peroxidation, and marked changes in carbohydrate composition of membrane glycoprotein receptors. Fluvastatin significantly improved lipid composition and peroxidation in plasma and neutrophils and caused positive dynamics in their aggregation due to optimization of glycoprotein receptors.