Clinicopathologic Characteristics and Outcome of Isolated Ovarian Relapse in Adolescent with Acute Lymphoblastic Leukemia

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 24; no. 5; p. 1354
• Main Authors: Yu, Ya-Ping, Song, Ping, Mei, Jian-Gang, An, Zhi-Ming, Zhou, Xiao-Gang, Li, Feng, Wang, Li-Ping, Tang, Yu-Mei, Zhai, Yong-Ping
• Format: Journal Article
• Language: Chinese
• Published: China 01-10-2016
• Subjects: Acute Disease; Adolescent; Antigens, CD19; B-Lymphocytes; Bone Marrow; Female; Flow Cytometry; HLA-DR Antigens; Humans; Lymphoma, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence
• ISSN: 1009-2137
• DOI: 10.7534/j.issn.1009-2137.2016.05.013

To investigate the clinicopathologic characteristics,diagnosis and treatment of isolated ovarian relapse of acute lymphoblastic leukemia(ALL).
A 16-year-old girl presented with complaints of bone and joint pain. The peripheral blood and bone marrow(BM) smears showed 32% and 72% blasts, respectively, which were myeloperoxidase-negative. The blasts were positive for HLA-DR, TdT, CD10, CD19, CD22 and cCD79a and negative for CD34, CD5, CD7, CD13, CD33, CD56 and MPO detected by flow cytometry. BM cytogenetic analysis and fusion gene screening revealed t(1;19)(q23;p13) and E2A/PBX1. She was diagnosed as B-cell acute lymphoblastic leukemia (B-ALL) and was treated with CALGB8811 protocol. She presented lower abdominal pain with intermittent colick at 7 months after complete remission. The pelvic ultrasound showed a lobulated mixed echogenic mass in the right ovary, and an exploratory laparotomy was performed.
Pathologic examination and immunohistochemistry of resected ovarian tumor revealed extensive infiltration by