The anti-inflammatory effect of 0.1% bromfenac and 0.1% betamethasone combination in post-cataract surgery patients with diabetes mellitus

• Published in: Nippon Ganka Gakkai zasshi Vol. 118; no. 8; p. 645
• Main Authors: Terada, Yukiko, Masuda, Ayami, Nejima, Ryohei, Maruyama, Yoko, Miyata, Kazunori
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-08-2014
• Subjects: Aged; Aged, 80 and over; Anti-Inflammatory Agents - therapeutic use; Benzophenones - therapeutic use; Betamethasone - therapeutic use; Bromobenzenes - therapeutic use; Cataract; Cataract Extraction - methods; Diabetes Complications; Drug Therapy, Combination - methods; Female; Humans; Macular Edema - drug therapy; Male; Middle Aged; Postoperative Complications - prevention & control
• ISSN: 0029-0203

To compare the post cataract surgery anti-inflammatory effect of bromfenac monotherapy and of bromfenac and betamethasone combination therapy in diabetes mellitus patients.
A prospective study approved by the Institutional Review Board. Fifty-one eyes of 51 patients were randomly allocated to either bromfenac 0.1% monotherapy (n = 23) or combined therapy with bromfenac 0.1% and betamethasone 0.1% (n = 28). After surgery, monotherapy group was administered bromfenac alone for 8 weeks, while the combined therapy group was administered both bromfenac and betamethasone for 2 weeks, bromfenac alone for the next 6 weeks. The amount of change from preoperative values in anterior chamber flare and foveal thickness were compared between the 2 groups.
There was no significant difference in change in anterior chamber flare between the 2 groups. The increase in foveal thickness 4 weeks postoperatively was significantly larger in the bromfenac group (p = 0.0356). Four patients of the bromfenac group, all with a history of diabetic macular edema, developed macular edema after surgery.
Bromfenac and betamethasone combination exhibited a stronger anti-inflammatory effect after cataract surgery patients with diabetes mellitus. In particular, patients with a history of diabetic macular edema were susceptible to foveal thickening and macular edema, and a combined treatment is desirable.